1337 Bilirubin nanomedicine alleviates inflammation and angiogenesis in a rosacea mouse model

Rosacea is a common chronic inflammatory facial disorder. Reactive oxygen species (ROS) have key role in the pathogenesis of rosacea. In this study, antioxidant and anti-inflammatory effects bilirubin-based nanoparticles (BRNPs) were investigated LL-37-induced rosacea-like mouse model. Effects BRNPs on skin inflammation ROS level determined using histological analysis. The expression genes encoding rosacea-associated cytokines chemokines was assessed molecular mechanisms against rosacea RNA sequencing (RNAseq) Our study reveals that significantly alleviated manifestation model reduced pro-inflammatory (interleukin [IL]-1β, IL-6, tumor necrosis factor [TNF]-α) (C-X-C motif chemokine ligand 8 [CXCL8] CXCL10). Moreover, preferentially localized at lesion, decreased skin, ameliorated vascular endothelial growth changes induced by LL-37. Furthermore, our findings provide mechanism for efficacy experimental support as potential therapeutic option other related disorders.